The theory of once saved always states that when a person accepts Jesus as the personal Savior and repents from their sins their salvation cannot be taken from them or lost. The simple answer to this question is No.
Salvation is a process not an event, that must be walked out every day through trials and tribulations and having done all, to stand firm, stand (Ephesians 6:13-14). More on the theory of once saved always saved is below as well as rebuttals to the theory.